Effects of NZ-105 on vascular smooth muscles and cardiac muscles
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چکیده
منابع مشابه
Calcium Antagonistic Activity of Biophytum Petersianum on Vascular Smooth Muscles of Wistar Rat
The whole plant of Biophytum petersianum was extracted with a mixture of water – alcohol (1:1) to evaluate its relaxant effect on aorta rings. In isolated Wistar rat tissue, the hydro-ethanolic extract (0.1; 0.25 and 0.5 mg/ml) non-competitively antagonized calcium chloride and high-K + - induced aorta contractions in a concentration-dependent manner. Moreover, the inhibition of noradr...
متن کاملThe Electrical Activity of Vascular Smooth Muscles.
岳中 典男 The electrophysiological investigation of vascular smooth muscles will permit a possible way of analyzing the mode of action of vasoactive substances. For an approach to the study the poten tial changes were recorded by means of external wick-Ag-AgC1 electrodes (1, 2). The rabbit or guinea pig aorta, dog renal artery and pig coronary artery were dissected and cut spirally. A strip prepara...
متن کاملSmooth Muscles
Results. In general, CNP and SNP exerted differential inhibitoiy effects on muscarinic-receptorinduced responses in CM and Sph isolated from the various species. Thus in bovine CM, SNP stimulated cGMP formation in a timeand concenu^ation-dependent manner and dose dependently inhibited CCh-induced IP3 production and contraction. These effects were inhibited by LY 83583, a soluble guanylyl cyclas...
متن کاملcalcium antagonistic activity of biophytum petersianum on vascular smooth muscles of wistar rat
the whole plant of biophytum petersianum was extracted with a mixture of water – alcohol (1:1) to evaluate its relaxant effect on aorta rings. in isolated wistar rat tissue, the hydro-ethanolic extract (0.1; 0.25 and 0.5 mg/ml) non-competitively antagonized calcium chloride and high-k + - induced aorta contractions in a concentration-dependent manner. moreover, the inhibition of noradrenaline–i...
متن کاملImmunolocalization of Meta-Vinculin in Human Smooth and Cardiac Muscles
Meta-vinculin, a vinculin-related protein, has been isolated from human uterus smooth muscle. Specific antibodies to meta-vinculin, which distinguish between meta-vinculin and vinculin, were prepared by absorption of anti-meta-vinculin serum on vinculin coupled to nitrocellulose. Meta-vinculin specific antibody demonstrates only smooth and cardiac muscle specificity and is able to cross-react w...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)56709-9